Fucosterol

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities[1][2]. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research[1].

Product Specifications

CAS Number

[17605-67-3]

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Endogenous Metabolite; PARP

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fucosterol.html

Purity

98.27

Solubility

DMSO : < 1 mg/mL|Ethanol : 16.67 mg/mL (ultrasonic)

Smiles

C/C=C(C(C)C)/CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4CC(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C29H48O

Molecular Weight

412.69

Precautions

H315, H319

References & Citations

[1]Jung HA, et al. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 2014 Jun;37 (6) :713-20.|[2]Lee YS, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res. 2004 Nov;27 (11) :1120-2.|[3]Khanavi M, et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn Mag. 2012 Jan;8 (29) :60-4.|[4]Caamal-Fuentes E, et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm Biol. 2014 Oct;52 (10) :1244-8.|[5]Qudeer Ahmed Abdul, et al. Health benefit of fucosterol from marine algae: a review. J Sci Food Agric. 2016 Apr;96 (6) :1856-66