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SJ46411-Br

SJ46411-Br is one of CRL2KLHDC2 targeting Ligands for E3 Ligase. SJ46411-Br can bind to KLHDC2 to form a complex to promote cooperative homologous selective ternary complex formation. SJ46411-Br can be coupled to BET ligand JQ1 through PROTAC linker to synthesize corresponding PROTACs[1].

Product Specifications

UNSPSC

12352005

Target

Ligands for E3 Ligase; Molecular Glues

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sj46411-br.html

Smiles

BrC1=CC=CC2=CC=C(C3=NC(CC(NCC(O)=O)=O)=CS3)C=C21

Molecular Formula

C17H13BrN2O3S

Molecular Weight

405.27

References & Citations

[1]Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15 (1) :8829.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Von Hippel-Lindau (VHL)

Frequently Asked Questions

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