SJ46411-Br
SJ46411-Br is one of CRL2KLHDC2 targeting Ligands for E3 Ligase. SJ46411-Br can bind to KLHDC2 to form a complex to promote cooperative homologous selective ternary complex formation. SJ46411-Br can be coupled to BET ligand JQ1 through PROTAC linker to synthesize corresponding PROTACs[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase; Molecular Glues
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj46411-br.html
Smiles
BrC1=CC=CC2=CC=C(C3=NC(CC(NCC(O)=O)=O)=CS3)C=C21
Molecular Formula
C17H13BrN2O3S
Molecular Weight
405.27
References & Citations
[1]Scott DC, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15 (1) :8829.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
SHIP (INPP5D) (Center) Rabbit Polyclonal Antibody
