Diclofenac (Sodium)

Diclofenac Sodium (GP 45840) is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac Sodium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

Product Specifications

CAS Number

[15307-79-6]

Product Name Alternative

GP 45840

UNSPSC

12352005

Hazard Statement

H301, H361, H372, H411

Target

Apoptosis; COX

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Diclofenac-Sodium.html

Concentration

10mM

Purity

99.94

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[Na])CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl

Molecular Formula

C14H10Cl2NNaO2

Molecular Weight

318.13

Precautions

H301, H361, H372, H411

References & Citations

[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121 (1) :105-17.|[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.|[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66 (2) :289-95.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

COX-1; COX-2

Citation 01

ACS Infect Dis. 2024 Aug 9;10 (8) :2860-2869.|Arch Microbiol. 2024 Jun 7;206 (7) :289.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Phys Chem Chem Phys. 2016 Jan 21;18 (3) :1526-36. |Toxicol Mech Methods. 2019 Nov;29 (9) :654-664.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Biomater Res. 2025 Nov 7:29:0280.|Biomater Res. 2025 Oct 22.|bioRxiv. 2024 Apr 7.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cell Rep. 2025 Feb 7;44 (2) :115263.|Chem Biol Interact. 2021 Apr 1:338:109425.|Chemosphere. 2019 Jun:225:378-387.|Ecotoxicol Environ Saf. 2025 Nov 15:307:119433.|Eur J Drug Metab Pharmacokinet. 2022 Sep;47 (5) :639-652.|Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS) . 2017 Nov.|Int J Mol Sci. 2022 Oct 11;23 (20) :12066.|J Hazard Mater. 2015 May 30;289:18-27.|J Pharm Biomed Anal. 2021 Jul 15:201:114105.|J Phys Chem Solids. 2017 October;109:117-123.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Pharm Res. 2022 Oct;39 (10) :2515-2527.