JWG-071
JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively[1].
Product Specifications
CAS Number
[2250323-50-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/JWG-071.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC(C(N2CCC(N3CCN(C)CC3)CC2)=O)=CC=C1NC4=NC=C(N(C)C5=O)C(N(C6=CC=CC=C65)C(C)CC)=N4
Molecular Formula
C34H44N8O3
Molecular Weight
612.76
Precautions
H302, H315, H319
References & Citations
[1]Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13 (9) :2438-2448
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK5
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