JWG-071
JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively[1].
Product Specifications
CAS Number
[2250323-50-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/JWG-071.html
Purity
99.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC(C(N2CCC(N3CCN(C)CC3)CC2)=O)=CC=C1NC4=NC=C(N(C)C5=O)C(N(C6=CC=CC=C65)C(C)CC)=N4
Molecular Formula
C34H44N8O3
Molecular Weight
612.76
Precautions
H302, H315, H319
References & Citations
[1]Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13 (9) :2438-2448
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK5
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
E1589Mo 96 Tests
Mouse Wisp2/WNT1-inducible-signaling pathway protein 2 ELISA Kit
Sign In for Pricing
View Details N5375-15 50 µg
Notch2 (Notch homolog 2, Drosophila, hN2) discontinued
Sign In for Pricing
View Details MBS2102979-01 5x 96 Tests
Human Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) Antibody Pair Kit (with Standard)
Sign In for Pricing
View Details MBS2102979-02 5x 96 Tests + MBS2090685 (Ab Pairs Support Pack 1,5x 96 Tests)
Human Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) Antibody Pair Kit (with Standard)
Sign In for Pricing
View Details 
MBS2102979-03 10x 96 Tests
Human Proprotein Convertase Subtilisin/Kexin Type 5 (PCSK5) Antibody Pair Kit (with Standard)
Sign In for Pricing
View Details