JWG-071

JWG-071 is the kinase-selective chemical probe for ERK5. JWG-071 inhibits ERK5 and LRRK2 with IC50 values of 88nM and 109 nM, respectively[1].

Product Specifications

CAS Number

[2250323-50-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

ERK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/JWG-071.html

Purity

99.15

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC(C(N2CCC(N3CCN(C)CC3)CC2)=O)=CC=C1NC4=NC=C(N(C)C5=O)C(N(C6=CC=CC=C65)C(C)CC)=N4

Molecular Formula

C34H44N8O3

Molecular Weight

612.76

Precautions

H302, H315, H319

References & Citations

[1]Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13 (9) :2438-2448

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ERK5

Available Sizes

More Discoveries

Explore Other Products

Browse additional items from our catalog

TBZ1375 unit

Halitunal

View Details

ORF024024 1.0 µg DNA

MIR320B1 ORF Vector (Human) (pORF)

View Details

NBP2-98799AF647 0.1 mL

Rabbit Polyclonal GAS2 Antibody [Alexa Fluor 647]

View Details

NBP3-11445AF594 0.1 mL

Mouse Monoclonal CD43/Sialophorin Antibody (84-3C1) [Alexa Fluor 594]

View Details

GA116700 1 Kit

Human DEFB107A activation kit by CRISPRa

View Details

bs-7411R-BF750 100 µL

Pantophysin Polyclonal Antibody, AbBy Fluor™ 750 Conjugated

View Details