SKL2001 (GMP)
SKL2001 (GMP) is SKL2001 produced by using GMP guidelines. SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction[1].
Product Specifications
CAS Number
909089-13-0
UNSPSC
12352005
Target
Wnt; β-catenin
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/skl2001-gmp.html
Smiles
O=C(C1=NOC(C2=CC=CO2)=C1)NCCCN3C=CN=C3
Molecular Formula
C14H14N4O3
Molecular Weight
286.29
References & Citations
[1]Gwak J, et al. Small molecule-based disruption of the Axin/β-catenin protein complex regulates mesenchymal stem cell differentiation. ell Res. 2012 Jan;22 (1) :237-47.|[2]Ohashi W, et al. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem Biophys Res Commun. 2017 Nov 25;493 (3) :1342-1348.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported
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