FPL 62064
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].
Product Specifications
CAS Number
103141-09-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fpl-62064.html
Purity
99.25
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC1=CC=C(NC2=NN(C3=CC=CC=C3)C=C2)C=C1
Molecular Formula
C16H15N3O
Molecular Weight
265.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30 (3-4) :432-42.|[2]Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim) . 2020 Feb 7:e1900308.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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