FPL 62064

FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC50 values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity[1][2].

Product Specifications

CAS Number

[103141-09-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fpl-62064.html

Purity

99.25

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

COC1=CC=C(NC2=NN(C3=CC=CC=C3)C=C2)C=C1

Molecular Formula

C16H15N3O

Molecular Weight

265.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Blackham A, et al. FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30 (3-4) :432-42.|[2]Shabaan MA, et al. Synthesis and biological evaluation of pyrazolone analogues as potential anti-inflammatory agents targeting cyclooxygenases and 5-lipoxygenase. Arch Pharm (Weinheim) . 2020 Feb 7:e1900308.