CYN 154806 (TFA)
Product Specifications
UNSPSC Description
CYN 154806 TFA, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2].
Target Antigen
Somatostatin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/cyn-154806-tfa.html
Purity
99.81
Solubility
H2O : 25 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC([C@@H](CSSC[C@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)C(N[C@@H](C(N)=O)CC2=CC=C(C=C2)O)=O)NC([C@@H](NC(C)=O)CC3=CC=C(C=C3)[N+]([O-])=O)=O)=O)CC4=CC=C(C=C4)O)N[C@@H]1CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
Molecular Weight
1311.36
References & Citations
[1]Bass RT, et al. Identification and characterization of novel somatostatin antagonists. Mol Pharmacol. 1996 Oct;50(4):709-15.|[2]Feniuk W, et al. Selective somatostatin sst(2) receptor blockade with the novel cyclic octapeptide, CYN-154806. Neuropharmacology. 2000 Jun 8;39(8):1443-50.|[3]Takeuchi K, et al. Activation of Muscarinic Acetylcholine Receptor Subtype 4 Is Essential for Cholinergic Stimulation of Gastric Acid Secretion: Relation to D Cell/Somatostatin. Front Pharmacol. 2016 Aug 30;7:278.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1202A/CYN-154806-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1202A/CYN-154806-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2828432-46-6
Available Sizes
Curated Selection
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