Vindesine (sulfate)

Vindesine sulfate is a potent tubulin inhibitor with an Ki of 0.110 μM. Vindesine sulfate shows anti-proliferation effect in vitro. Vindesine sulfate shows antitumor effect in vivo[1].

Product Specifications

CAS Number

[59917-39-4]

UNSPSC

12352005

Hazard Statement

H300, H318, H361

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vindesine-sulfate.html

Purity

99.91

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=S(O)(O)=O.CC[C@@]12[C@@]3([H])[C@@]4(CCN3CC=C2)C5=CC([C@@]6(C7=C(CC[N@]8C[C@@](C[C@](O)(C8)CC)([H])C6)C9=CC=CC=C9N7)C(OC)=O)=C(OC)C=C5N([C@@]4([H])[C@](O)([C@@H]1O)C(N)=O)C

Molecular Formula

C43H57N5O11S

Molecular Weight

852.00

Precautions

H300, H318, H361

References & Citations

[1]Jordan MA, et al. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 1985 Jun;45 (6) :2741-7.