Ro 10-5824 (dihydrochloride)

Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.

Product Specifications

CAS Number

[189744-94-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Ro_10-5824_dihydrochloride.html

Purity

99.86

Solubility

DMSO : 8.33 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

NC1=NC(C)=NC=C1CN2CC=C(C3=CC=CC=C3)CC2.[H]Cl.[H]Cl

Molecular Formula

C17H22Cl2N4

Molecular Weight

353.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Nakazawa S, et al. Behavioral and neurophysiological effects of Ro 10-5824, a dopamine D4 receptor partial agonist, in common marmosets. Psychopharmacology (Berl) . 2015 Sep;232 (17) :3287-95.|[2]Powell SB, et al. RO-10-5824 is a selective dopamine D4 receptor agonist that increases novel object exploration in C57 mice. Neuropharmacology. 2003 Mar;44 (4) :473-81.