SNIPER (BRD) -1
SNIPER (BRD) -1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER (BRD) -1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER (BRD) -1 can be used for cancer research[1]. (Blue: LCL161 ; Black: linker (HY-W008005) ; Pink: (+) -JQ-1 (HY-13030) )
Product Specifications
CAS Number
2095244-54-3
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Epigenetic Reader Domain; PROTACs; SNIPERs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sniper-brd-1.html
Purity
99.68
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5
Molecular Formula
C53H66ClN9O8S2
Molecular Weight
1056.73
Precautions
H302, H312, H332
References & Citations
[1]Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER) . Chem Pharm Bull (Tokyo) . 2019 Mar 1;67 (3) :203-209.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
FAB7638N-100UG 100 µg
Human Allergin-1 Alexa Fluor 700 Antibody (Clone 767727)
Sign In for Pricing
View Details