SNIPER (BRD) -1

SNIPER (BRD) -1 is a SNIPER degrader of BRD4, cIAP1 and XIAP. SNIPER (BRD) -1 has IC50 values of 6.8 nM, 17 nM and 49 nM for cIAP1, cIAP2 and XIAP, respectively. SNIPER (BRD) -1 can be used for cancer research[1]. (Blue: LCL161 (HY-15518) ; Black: linker (HY-W008005) ; Pink: (+) -JQ-1 (HY-13030) )

Product Specifications

CAS Number

[2095244-54-3]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Epigenetic Reader Domain; PROTACs; SNIPERs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sniper-brd-1.html

Purity

99.68

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

O=C(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@@H](NC([C@H](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5

Molecular Formula

C53H66ClN9O8S2

Molecular Weight

1056.73

Precautions

H302, H312, H332

References & Citations

[1]Ohoka N, et al. Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER) . Chem Pharm Bull (Tokyo) . 2019 Mar 1;67 (3) :203-209.