Tesirine intermediate-2
Tesirine intermediate-2 is the intermediate of Tesirine. Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Product Specifications
CAS Number
1430738-34-3
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tesirine-intermediate-2.html
Purity
99.43
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC(C)(C)[Si](C)(C)O[C@@H]1N(C2=CC(O)=C(OC)C=C2C(N3[C@@]1([H])CC(C)=C3)=O)C(OCC4=CC=C(C=C4)NC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O)=O
Molecular Formula
C40H55N5O10Si
Molecular Weight
793.98
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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