α-Synuclein (61-95) (human) (TFA)

α-Synuclein (61-95) (human) TFA is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) TFA can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) [1][2].

Product Specifications

UNSPSC

12352209

Target

α-synuclein

Type

Peptides

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-synuclein-61-95-human-tfa.html

Purity

96.61

Solubility

H2O : 0.62 mg/mL (ultrasonic; adjust pH to 9 with NH3·H2O)

Smiles

CC(C)[C@@H](C(O)=O)NC([C@@H](NC(CNC([C@H]([C@H](O)C)NC([C@H](C)NC([C@H](C)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC(CNC([C@H](C)NC(CNC([C@H](CCC(O)=O)NC([C@H](C(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](C)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC(CNC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](C(C)C)NC([C@H](C)NC(CNC(CNC([C@H](C(C)C)NC([C@H](CC(N)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O.O=C(O)C(F)(F)F.[x]

Molecular Formula

C141H235N39O49.xC2HF3O2

Molecular Weight

3260.61 (free base)

References & Citations

[1]Tabner BJ, et al. Formation of hydrogen peroxide and hydroxyl radicals from A (beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radic Biol Med. 2002 Jun 1;32 (11) :1076-83.|[2]Emadi S, et al. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry. 2004 Mar 16;43 (10) :2871-8.