Hydrocortisone hemisuccinate (sodium)

Hydrocortisone hemisuccinate sodium is an orally active physiological glucocorticoid. Hydrocortisone hemisuccinate sodium inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate sodium can be used for the research of ulcerative colitis (UC) [1].

Product Specifications

CAS Number

[125-04-2]

Product Name Alternative

Hydrocortisone 21-hemisuccinate (sodium)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hydrocortisone-hemisuccinate-sodium.html

Purity

99.66

Solubility

DMSO : 175 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@](C(COC(CCC(O[Na])=O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

Molecular Formula

C25H33NaO8

Molecular Weight

484.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24 (6) :701-3.|[2]You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53.|[3]Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9 (4) :469-73.