ADAMTS-5 Inhibitor
ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) [1].
Product Specifications
CAS Number
929634-33-3
Product Name Alternative
6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528224,Alvocidib (Hydrochloride); L86-8275 (Hydrochloride); HMR-1275 (Hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
ADAMTS
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/adamts-5-inhibitor.html
Concentration
10mM
Purity
99.59
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1NC(S/C1=C\C2=C(SCC3=CC=C(Cl)C=C3)N(C)N=C2C(F)(F)F)=S
Molecular Formula
C16H11ClF3N3OS3
Molecular Weight
449.92
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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