ADAMTS-5 Inhibitor

ADAMTS-5 Inhibitor is a potent ADAMTS-5 (aggrecanase-2) inhibitor, with an IC50 of 1.1 µM. ADAMTS-5 Inhibitor shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1) [1].

Product Specifications

CAS Number

[929634-33-3]

Product Name Alternative

6-Hydroxybuspirone; 6'-Hydroxybuspirone; BMS 528224,Alvocidib (Hydrochloride); L86-8275 (Hydrochloride); HMR-1275 (Hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

ADAMTS

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/adamts-5-inhibitor.html

Concentration

10mM

Purity

99.59

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1NC(S/C1=C\C2=C(SCC3=CC=C(Cl)C=C3)N(C)N=C2C(F)(F)F)=S

Molecular Formula

C16H11ClF3N3OS3

Molecular Weight

449.92

Precautions

H302, H315, H319

References & Citations

[1]Gilbert AM, et al. 5- ((1H-pyrazol-4-yl) methylene) -2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg Med Chem Lett. 2007 Mar 1;17 (5) :1189-92.|[2]Wylie JD, et al. Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines. J Orthop Res. 2012 Feb;30 (2) :226-33.