JNJ-64264681
JNJ-64264681 is a potent, orally active, selective and irreversible covalent BTK inhibitor. JNJ-64264681 exhibits good pharmacokinetic characteristics and can be used for cancer and autoimmune diseases research[1].
Product Specifications
CAS Number
2101524-34-7
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-64264681.html
Purity
98.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CC(N[C@@H](CCC1)[C@@H]1NC(C2=C3C4=C(C=CN=C4S2)N(C5=CN=C(CC(C)C)C=C5C)C(N3)=O)=O)=O
Molecular Formula
C27H30N6O3S
Molecular Weight
518.63
References & Citations
[1]Mark S Tichenor, et al. Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2022 Nov 10;65 (21) :14326-14336.|[2]Mark S Tichenor, et al. Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem. 2022 Nov 10;65 (21) :14326-14336.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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