Cabozantinib (Standard)
Cabozantinib (Standard) is the analytical standard of Cabozantinib. This product is intended for research and analytical applications. Cabozantinib is a potent and orally active inhibitor of VEGFR2 and MET, with IC50 values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, TIE2, and FLT3 (IC50=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively) . Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis[1][2].
Product Specifications
CAS Number
849217-68-1
Product Name Alternative
XL184 (Standard) ; BMS-907351 (Standard)
UNSPSC
12352005
Target
Apoptosis; c-Kit; c-Met/HGFR; FLT3; Reference Standards; TAM Receptor; VEGFR
Type
Reference Standards
Related Pathways
Apoptosis; Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cabozantinib-standard.html
Purity
99.33
Smiles
O=C(C1(CC1)C(NC2=CC=C(F)C=C2)=O)NC3=CC=C(C=C3)OC4=C5C=C(OC)C(OC)=CC5=NC=C4
Molecular Formula
C28H24FN3O5
Molecular Weight
501.51
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Available Sizes
Frequently Asked Questions
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