AY254
AY254 is an analogue of AY77 (HY-138951) . AY254 is ERK-biased PAR2 agonist with an EC50 of 2 nM. AY254 relieves cytokine-induced caspase 3/8 activation. AY254 also promotes scratch-wound healing and induced IL-8 secretion via PAR2-ERK1/2 signaling[1]
Product Specifications
CAS Number
[2093408-03-6]
UNSPSC
12352209
Target
Protease Activated Receptor (PAR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ay254.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=NO1)N[C@@H](CC2CCCCC2)C(N[C@@H](C3CCCCC3)C(N[C@@H](C)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O
Molecular Formula
C30H49N9O6
Molecular Weight
631.77
References & Citations
[1]Jiang Y, et al. Biased Signaling by Agonists of Protease Activated Receptor 2. ACS Chem Biol. 2017 May 19;12 (5) :1217-1226.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
PAR2
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