ATX-002
ATX-002 is an ionizable cationic lipid for RNA drug delivery. The calculated pKa (c-pKa) and measured pKa values for ATX-002 are 8.68 and 6.03, respectively[1].
Product Specifications
CAS Number
[1777792-34-3]
UNSPSC
12352211
Target
Liposome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/atx-002.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CN(C)CCSC(N(CCCCCCCC(OC/C=C\CCCCCC)=O)CCCCCCCC(OC/C=C\CCCCCC)=O)=O
Molecular Formula
C39H72N2O5S
Molecular Weight
681.06
References & Citations
[1]Rajappan K, et al. Property-Driven Design and Development of Lipids for Efficient Delivery of siRNA. J Med Chem. 2020 Nov 12;63 (21) :12992-13012. |[2]Ramaswamy S, et al., Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proc Natl Acad Sci U S A. 2017 Mar 7;114 (10) :E1941-E1950.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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