Adropin (34-76) (human, mouse, rat)
Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway[1][2].
Product Specifications
CAS Number
1802086-30-1
UNSPSC
12352209
Target
Akt; Gli; JNK; PKA
Type
Peptides
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/adropin-34-76-human-mouse-rat.html
Purity
98.23
Solubility
DMSO : 100 mg/mL
Smiles
O=C(O)[C@H]1N(C([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC2=CC=C(C=C2)O)NC([C@H](CO)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC3=CNC=N3)NC([C@H](CO)NC([C@H]4N(C([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H]5N(C([C@H]6N(C([C@H]7N(C([C@H](C)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H]8N(C([C@H](CSSC[C@@H]9N)NC([C@H]%10N(C(CNC([C@H]%11N(C([C@H](CO)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H]%12N(C([C@H](CO)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC%13=CNC=N%13)NC9=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC%12)=O)=O)=O)=O)CCC%11)=O)=O)CCC%10)=O)=O)CCC8)=O)=O)=O)=O)CCC7)=O)CCC6)=O)CCC5)=O)=O)=O)CCC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1
Molecular Formula
C190H293N55O68S2
Molecular Weight
4499.82
References & Citations
[1]Gao S, et al. The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity. J Biol Chem. 2019 Sep 6;294 (36) :13366-13377.|[2]Liang M, et al. Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis. Sci Transl Med. 2024 Mar 27;16 (740) :eadd6570.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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