Adropin (34-76) (human, mouse, rat)

Adropin (34-76) is a secretory domain of Adropin. Adropin (34-76) can inhibit cAMP level and glucose production in hepatocytes, and has a hypoglycemic effect. Adropin (34-76) plays an antifibrotic role by inhibiting the GLI1 signaling pathway[1][2].

Product Specifications

CAS Number

[1802086-30-1]

UNSPSC

12352209

Target

Akt; Gli; JNK; PKA

Type

Peptides

Related Pathways

MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/adropin-34-76-human-mouse-rat.html

Purity

98.23

Solubility

DMSO : 100 mg/mL

Smiles

O=C(O)[C@H]1N(C([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC2=CC=C(C=C2)O)NC([C@H](CO)NC(CNC([C@H](CCC(O)=O)NC([C@H](CC3=CNC=N3)NC([C@H](CO)NC([C@H]4N(C([C@H](CCCCN)NC([C@H](CCC(N)=O)NC([C@H]5N(C([C@H]6N(C([C@H]7N(C([C@H](C)NC([C@H](CCCCN)NC([C@H](CCC(O)=O)NC([C@H]8N(C([C@H](CSSC[C@@H]9N)NC([C@H]%10N(C(CNC([C@H]%11N(C([C@H](CO)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H]%12N(C([C@H](CO)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@H](CC%13=CNC=N%13)NC9=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC%12)=O)=O)=O)=O)CCC%11)=O)=O)CCC%10)=O)=O)CCC8)=O)=O)=O)=O)CCC7)=O)CCC6)=O)CCC5)=O)=O)=O)CCC4)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1

Molecular Formula

C190H293N55O68S2

Molecular Weight

4499.82

References & Citations

[1]Gao S, et al. The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity. J Biol Chem. 2019 Sep 6;294 (36) :13366-13377.|[2]Liang M, et al. Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis. Sci Transl Med. 2024 Mar 27;16 (740) :eadd6570.