DCE_254

DCE_254 is an EZH2 inhibitor (IC50=11 μM) that also exhibits significant antiproliferative activity against lymphoma cell lines. DCE_254 inhibits the development of hypermethylation-related cancers by inhibiting the SAM-mediated methyl transfer process (IC50=10.3 μM) [1].

Product Specifications

CAS Number

[673443-80-6]

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dce-254.html

Smiles

O=C1N=C(NC(CSC2=NN=NN2C3=CC=CC=C3)=C1)NC4=NC(C)=C5C=CC=CC5=N4

Molecular Formula

C21H17N9OS

Molecular Weight

443.48

References & Citations

[1]Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays[J]. Bioorganic & Medicinal Chemistry Letters, 2016, 26 (15) : 3813-3817.