Girinimbine

Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3].

Product Specifications

CAS Number

[23095-44-5]

Product Name Alternative

Girinimbin

UNSPSC

12352005

Target

Apoptosis; Bacterial; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/girinimbine.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

CC(OC1=C(C)C=C23)(C)C=CC1=C3NC4=C2C=CC=C4

Molecular Formula

C18H17NO

Molecular Weight

263.33

References & Citations

[1]Suvitha Syam, et al. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011 Aug 23;16 (8) :7155-70.|[2]Venoos Iman, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2016 Dec 28;11:103-121.|[3]H O Dyary, et al. Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Trop Biomed. 2019 Mar 1;36 (1) :94-102.