K-14585
K-14585 is a peptide competitive PAR2 antagonist. K-14585 inhibits PAR2-dependent IL-8 production, NF-κB phosphorylation, and p38 signaling. K-14585 reduces SLIGKV (PAR2 agonist peptide) -induced Ca2+ mobilisation in primary human keratinocytes[1][2][3].
Product Specifications
CAS Number
880546-17-8
UNSPSC
12352005
Target
NF-κB; p38 MAPK; Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/k-14585.html
Smiles
ClC(C=CC=C1Cl)=C1CN2C(C(C(CN3CCCC3)=C2)=C4)=CC=C4NC(NCC(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=CC=C5)C(NC(C6=CC=CC=C6)C7=CC=CC=C7)=O)=O)=O)=O
Molecular Formula
C51H56Cl2N8O4
Molecular Weight
915.95
References & Citations
[1]Goh FG, et al. Dual effect of the novel peptide antagonist K-14585 on proteinase-activated receptor-2-mediated signalling. Br J Pharmacol. 2009 Dec;158 (7) :1695-704.|[2]Kanke T, et al. Novel antagonists for proteinase-activated receptor 2: inhibition of cellular and vascular responses in vitro and in vivo. Br J Pharmacol. 2009 Sep;158 (1) :361-71. |[3]Sevigny LM, et al. Interdicting protease-activated receptor-2-driven inflammation with cell-penetrating pepducins. Proc Natl Acad Sci U S A. 2011 May 17;108 (20) :8491-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PAR2
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