Methapyrilene (hydrochloride)

Methapyrilene (Thenylpyramine) hydrochloride is an orally active H1-receptor antihistamine and an anticholinergic agent of the pyridine chemical class. Methapyrilene hydrochloride has hepatotoxicity and can be used as a hepatotoxin that cause periportal hepatic necrosis in vivo[2]

Product Specifications

CAS Number

[135-23-9]

Product Name Alternative

Thenylpyramine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/methapyrilene-hydrochloride.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCN(C1=NC=CC=C1)CC2=CC=CS2.[H]Cl

Molecular Formula

C14H20ClN3S

Molecular Weight

297.85

Precautions

H301

References & Citations

[1]Iryna Kindrat, et al.Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro. Toxicol Lett. 2017 Nov 5;281:65-73.|[2]Andrew Craig, et al. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res. 2006 Jul;5 (7) :1586-601.|[3]Shawkat-Muhialdin Jangi, et al. H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells. Carcinogenesis. 2006 Sep;27 (9) :1787-96.