Acivicin
Acivicin (AT-125), a natural product produced by Streptomyces sviceus is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
Product Specifications
CAS Number
42228-92-2
Product Name Alternative
AT-125; U-42126
UNSPSC
12352005
Hazard Statement
H301
Target
Parasite; γ-Glutamyl Transferase (GGT)
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/acivicin.html
Purity
99.52
Solubility
H2O : 6.67 mg/mL (ultrasonic)
Smiles
ClC1=NO[C@@]([C@H](N)C(O)=O)([H])C1
Molecular Formula
C5H7ClN2O3
Molecular Weight
178.57
Precautions
H301
References & Citations
[1]Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6 (1) :237-245. Epub 2014 Sep 26.|[2]Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49 (7) :941-5.|[3]Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30 (3) :154-60.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
Phase 3
Available Sizes
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