Vinpocetine
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].
Product Specifications
CAS Number
42971-09-5
Product Name Alternative
Ethyl apovincaminate
UNSPSC
12352005
Hazard Statement
H302
Target
IKK; Phosphodiesterase (PDE) ; Sodium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Vinpocetine.html
Purity
99.87
Solubility
DMSO : 6.25 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic)
Smiles
CCOC(C1=C[C@]2(CC)CCCN3CCC(C4=C(C=CC=C4)N51)=C5[C@]23[H])=O
Molecular Formula
C22H26N2O2
Molecular Weight
350.45
Precautions
H302
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
IKK
Available Sizes
Frequently Asked Questions
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