Gynostemma Extract

Gynostemma Extract (Gypenoside IX) is a triterpenoid saponin. Gynostemma Extract can be isolated from Panax notoginseng. Gynostemma Extract reduces NFκB nuclear translocation and transcriptional activity by inhibiting the p38 MAPK/Akt/NFκB signaling pathway. Gynostemma Extract reduces the expression of cytokines (COX-2, IL-6) and the production of NO. Gynostemma Extract has anti-inflammatory activity. Gynostemma Extract can be used in the study of liver injury and neuroinflammation[1][2].

Product Specifications

CAS Number

[80321-63-7]

Product Name Alternative

Ginsenoside C-Mx1; Gypenoside IX

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; COX; Interleukin Related; NF-κB; NO Synthase; p38 MAPK

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Gynostemma-Extract.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]2C(C)(C)[C@@](CC[C@]3(C)[C@]4([H])C[C@@H](O)[C@@]5([H])[C@@]3(C)CC[C@@H]5[C@](O[C@@H]6O[C@H](CO[C@@H]7OC[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O)(C)CC/C=C(C)\C)([H])[C@]4(C)CC2)[C@@H]1O

Molecular Formula

C47H80O17

Molecular Weight

917.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Yoshikawa M, et al. Structures of new dammarane-type Triterpene Saponins from the flower buds of Panax notoginseng and hepatoprotective effects of principal Ginseng Saponins. J Nat Prod. 2003 Jul;66 (7) :922-7. |[2]Wang X, et al. Gypenoside IX Suppresses p38 MAPK/Akt/NFκB Signaling Pathway Activation and Inflammatory Responses in Astrocytes Stimulated by Proinflammatory Mediators. Inflammation. 2017 Dec;40 (6) :2137-2150.