IMDK
IMDK is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK) . iMDK suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice[1].
Product Specifications
CAS Number
881970-80-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/imdk.html
Purity
99.35
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CN3C(SC(CC4=CC=C(F)C=C4)=C3)=N2)=CC5=CC=CC=C5O1
Molecular Formula
C21H13FN2O2S
Molecular Weight
376.40
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Cell Discov. 2024 Oct 22;10 (1) :110.|IUBMB Life. 2025 May;77 (5) :e70014.|Nat Commun. 2023 Jul 31;14 (1) :4600.
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