DSG1 antibody
Product Specifications
Background
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma.
Synonyms
Desmoglein-1|Cadherin family member 4|Desmosomal glycoprotein 1 (DG1, DGI)|Pemphigus foliaceus antigen|DSG1|CDHF4
Host
Rabbit
Reactivity
Human, Rat
Immunogen
Desmoglein-1
Target
DSG1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
CAS Number
9007-83-4
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