1,1-Dimethylethyl 4- (5-amino-3-pyridinyl) -1-piperazinecarboxylate
1,1-Dimethylethyl 4- (5-amino-3-pyridinyl) -1-piperazinecarboxylate is the impurity of Palbociclib. Palbociclib is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively[1].
Product Specifications
CAS Number
1245914-05-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-1-dimethylethyl-4-5-amino-3-pyridinyl-1-piperazinecarboxylate.html
Purity
99.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(C2=CC(N)=CN=C2)CC1)OC(C)(C)C
Molecular Formula
C14H22N4O2
Molecular Weight
278.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3 (11) :1427-38.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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