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Anamorelin (hydrochloride)

Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC50 of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia[1][2].

Product Specifications

CAS Number

861998-00-7

Product Name Alternative

RC-1291 (hydrochloride) ; ONO-7643 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

GHSR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Anamorelin-hydrochloride.html

Purity

99.59

Solubility

DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[H][C@](CC1=CNC2=CC=CC=C21)(NC(C(C)(C)N)=O)C(N3CCC[C@@](C(N(C)N(C)C)=O)(CC4=CC=CC=C4)C3)=O.[H]Cl

Molecular Formula

C31H43ClN6O3

Molecular Weight

583.16

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Pietra C, et al. Anamorelin HCl (ONO-7643), a novel ghrelin receptor agonist, for the treatment of cancer anorexia-cachexiasyndrome: preclinical profile. J Cachexia Sarcopenia Muscle. 2014 Dec;5 (4) :329-37.|[2]Northrup R, et al. Effect of ghrelin and anamorelin (ONO-7643), a selective ghrelin receptor agonist, on tumor growth in a lung cancer mouse xenograft model. Support Care Cancer. 2013 Sep;21 (9) :2409-15.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Patent. US20240139176A1.|Patent. US20240197718A1.|Discov Med. 2024 Sep 17.|Drug Test Anal. 2021 Feb;13 (2) :283-298.|J Pharm Biomed Anal. 2016 Nov 30:131:482-496.|J Sep Sci. 2016 Jan;39 (2) :333-41.|Mass Spectrom Lett. 2016 Sep 30;7 (3) :55-63.|Mass Spectrom Lett. 2016, 7 (3) :55-63.|Universität Zürich. 2023 Jun 14.

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