Dimethyl phthalate

Dimethyl phthalate (DMP) can be used as a plasticizer to impart flexibility to rigid polyvinyl chloride (PVC) resin. Additionally, Dimethyl phthalate is an oral active endocrine disruptor that can cause ovarian dysfunction in mice. Dimethyl phthalate can also induce oxidative stress and apoptosis in cells, thereby affecting blood and red blood cell function in rats[1].

Product Specifications

CAS Number

[131-11-3]

Product Name Alternative

DMP

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Biochemical Assay Reagents; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dimethyl-phthalate.html

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1C(OC)=O)OC

Molecular Formula

C10H10O4

Molecular Weight

194.19

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang ZG, et al. Impacts of dimethyl phthalate on the bacterial community and functions in black soils. Front Microbiol. 2015 May 5;6:405.|[2]Kara M, et al. Investigation of the Neurotoxic Effects of Dimethyl Phthalate and Diisobutyl Phthalate on SH-SY5Y Neuroblastoma Cells[J]. Recent Trends in Pharmacology, 2024, 2 (3) : 101-108.|[3]Wang Z, et al. Dimethyl phthalate damaged the cell membrane of Escherichia coli K12. Ecotoxicol Environ Saf. 2019 Sep 30;180:208-214.|[4]Chi Z, et al. Revealing the toxicity of dimethyl phthalate (DMP) to the oxygen-carrying function of red blood cells (RBCs) : The iron release mechanism. Chemosphere. 2021 Jan;263:128017.|[5]Mei Y, et al. Effects of Dimethyl Phthalate (DMP) on Serum Sex Hormone Levels and Apoptosis in C57 Female Mice. Int J Endocrinol Metab. 2019 Apr 22;17 (2) :e82882.|[6]Yin H, et al. Dimethyl phthalate exposure induces cognitive impairment via COX2-mediated neuroinflammation. Ecotoxicol Environ Saf. 2024 Oct 1;284:117039.