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Dithiodipropionic acid

Dithiodipropionic acid can interact with CPUL1 (HY-151802) (a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs) . CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].

Product Specifications

CAS Number

[1119-62-6]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dithiodipropionic-acid.html

Concentration

10mM

Purity

99.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(O)CCSSCCC(O)=O

Molecular Formula

C6H10O4S2

Molecular Weight

210.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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