Lanuginosine

Lanuginosine is an alkaloid. Lanuginosine can be isolated from the stems of Xylopia laevigata (Annonaceae) and the leaves of Magnolia grandiflora. Lanuginosine induces Apoptosis. Lanuginosine inhibits AChE (IC50: 10.9 μM) . Lanuginosine inhibits Aβ aggregation. Lanuginosine exhibits anticancer activity against hepatocellular carcinoma, human promyelocytic leukemia, human chronic myeloid leukemia, melanoma, and brain tumors. Lanuginosine can be used in the research of Alzheimer's disease[1][2][3].

Product Specifications

CAS Number

[23740-25-2]

UNSPSC

12352005

Target

Amyloid-β; Apoptosis; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lanuginosine.html

Purity

98.27

Solubility

DMSO : 0.5 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)

Smiles

O=C1C2=CC(OC)=CC=C2C3=C4OCOC4=CC5=CC=NC1=C53

Molecular Formula

C18H11NO4

Molecular Weight

305.28

References & Citations

[1]Jiang K, et al. Bioactive Isoquinoline Alkaloids with Diverse Skeletons from Fissistigma polyanthum. J Nat Prod. 2023 Aug 24.|[2]Menezes LR, et al. Cytotoxic Alkaloids from the Stem of Xylopia laevigata. Molecules. 2016 Jul 8;21 (7) :890. |[3]Mohamed SM, et al. Cytotoxic and antiviral activities of aporphine alkaloids of Magnolia grandiflora L. Nat Prod Res. 2010 Sep;24 (15) :1395-402.