Imetit (dihydrobromide)

Imetit dihydrobromide (VUF 8325 dihydrobromide) is a high affinity and potent agonist of histamine H3 and H4 receptors, with Ki values of 0.3 and 2.7 nM, respectively. Imetit mimics histamine effect in triggering a shape change in eosinophils (EC50=25 nM) [1][2][3].

Product Specifications

CAS Number

[32385-58-3]

Product Name Alternative

VUF 8325 (dihydrobromide) ; SKF 91105 (dihydrobromide)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/imetit-dihydrobromide.html

Purity

98.16

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

NC(SCCC1=CN=CN1)=N.Br.Br

Molecular Formula

C6H12Br2N4S

Molecular Weight

332.06

Precautions

H302, H315, H319, H335

References & Citations

[1]Liu C, et al. Cloning and pharmacological characterization of a fourth histamine receptor (H (4) ) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59 (3) :420-6.|[2]Ling P, et al. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142 (1) :161-71.|[3]Garbarg M, et al. S-[2- (4-imidazolyl) ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J Pharmacol Exp Ther. 1992 Oct;263 (1) :304-10.|[4]Farzin D, et al. Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rat. Eur J Pharmacol. 2000 Sep 15;404 (1-2) :169-74.