Pan-KRAS-IN-16

Pan-KRAS-IN-16 (Compound 3344) is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines[1].

Product Specifications

CAS Number

[2368246-78-8]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pan-kras-in-16.html

Smiles

CN(C)CC1=CC(NC2=CC=C(C3=C4OCCOC4=CC=C3)C=C2OC)=CC=C1

Molecular Formula

C24H26N2O3

Molecular Weight

390.47

References & Citations

[1]Bery N, et al. BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife. 2018 Jul 10;7:e37122.