Icrocaptide
Product Specifications
UNSPSC Description
Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca2+-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders[1].
Target Antigen
P-selectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/icrocaptide.html
Smiles
NCC(N(CC)[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O
Molecular Weight
484.59
References & Citations
[1]Silvia Bertuglia, et al. ITF1697, a stable Lys-Pro-containing peptide, inhibits weibel-palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 2007 Nov-Dec;13(11-12):615-24.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-106428/Icrocaptide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-106428/
Clinical Information
No Development Reported
CAS Number
169543-49-1
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