Icrocaptide

Icrocaptide (ITF1697) is a stable Lys-Pro-containing peptide that inhibits the intracellular Ca2+-dependent fusion of Weibel-Palade bodies with the plasma membrane. Icrocaptide exerts its activity at the early stages of endothelial activation and inhibits P-selectin and von Willebrand factor secretion. Icrocaptide can be used for the study of a variety of microvascular disorders[1].

Product Specifications

CAS Number

[169543-49-1]

Product Name Alternative

ITF1697

UNSPSC

12352209

Target

P-selectin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/icrocaptide.html

Smiles

NCC(N(CC)[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O

Molecular Formula

C21H40N8O5

Molecular Weight

484.59

References & Citations

[1]Silvia Bertuglia, et al. ITF1697, a stable Lys-Pro-containing peptide, inhibits weibel-palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med. 2007 Nov-Dec;13 (11-12) :615-24.