Coronaridine
Product Specifications
UNSPSC Description
Coronaridine, an iboga type alkaloid, inhibits the wnt signaling pathway by decreasing β-catenin expression[1].
Target Antigen
Wnt
Type
Natural Products
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/coronaridine.html
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC([C@]12[C@@]3([H])[N@@](CCC4=C2NC5=CC=CC=C45)C[C@@](C[C@@H]3CC)([H])C1)=O
Molecular Weight
338.44
References & Citations
[1]Kensuke Ohishi, et al. Coronaridine, an iboga type alkaloid from Tabernaemontana divaricata, inhibits the Wnt signaling pathway by decreasing β-catenin mRNA expression. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3937-40.|[2]Hugo R Arias, et al. Coronaridine congeners potentiate GABA A receptors and induce sedative activity in mice in a benzodiazepine-insensitive manner. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Jul 13;101:109930
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121118/Coronaridine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121118/Coronaridine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
467-77-6
Available Sizes
Curated Selection
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