GS-704277

GS-704277 is an alanine metabolite of Remdesivir (HY-104077) . GS-704277 is further hydrolyzed to GA-441524 (HY-103586) with antiviral activity. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection[1][2][3][4][5].

Product Specifications

CAS Number

[1911579-04-8]

UNSPSC

12352005

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gs-704277.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC([C@H](C)NP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](C2=CC=C3N2N=CN=C3N)(C#N)O1)(O)=O)=O

Molecular Formula

C15H19N6O8P

Molecular Weight

442.32

References & Citations

[1]Eastman RT, et al. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 [published correction appears in ACS Cent Sci. 2020 Jun 24;6 (6) :1009]. ACS Cent Sci. 2020;6 (5) :672-683.|[2]Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30 (3) :269-271.|[3]Yan VC, et al. Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity. Antimicrob Agents Chemother. 2020 Nov 17;64 (12) :e01920-20.|[4]Sullivan JT. Postmarketing pharmacovigilance: Remdesivir and cardiovascular events. Clin Transl Sci. 2022 Apr;15 (4) :813-815.|[5]Prabha PK, et al. Can changing the prodrug moiety in remdesivir be a life-saving strategy in COVID-19 infection? Indian J Med Res. 2023 Jan;157 (1) :100-103.