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HLCL-61 (hydrochloride)

Product Specifications

UNSPSC Description

HLCL-61 hydrochloride is a first-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5).

Target Antigen

Apoptosis; Histone Methyltransferase

Type

Reference compound

Related Pathways

Apoptosis;Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/HLCL-61-hydrochloride.html

Purity

99.87

Solubility

DMSO : 50 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

[H]Cl.COC1=CC=CC=C1CNCC2=CC3=C(C=C2)N(CC)C4=C3C=CC=C4

Molecular Weight

380.91

References & Citations

[1]Tarighat SS, et al. The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation. Leukemia. 2016 Apr;30(4):789-99.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-100025A/HLCL-61-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-100025A/HLCL-61-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1158279-20-9

Available Sizes

Curated Selection

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