2-MNG

Product Specifications

CAS Number

[2101538-28-5]

UNSPSC Description

2-MNG (2-Mercaptonicotinoyl glycine) is an inhibitor for melanogenesis with an average IC50 of 49.5μM in normal human melanocytes. 2-MNG binds to melanin precursors, prevents the incorporation into growing melanin, and thereby inhibits the synthesis of eumelanin and pheomelanin. 2-MNG can be used in research about skin pigmentation[1].

Target Antigen

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-mng.html

Solubility

DMSO : 116.67 mg/mL (ultrasonic)

Smiles

O=C(O)CNC(C1=CC=CNC1=S)=O

Molecular Weight

212.23

References & Citations

[1]Sextius P, et al., 2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity. Pigment Cell Melanoma Res. 2024 Jul;37(4):462-479.