(R) -Equol
(R) -Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively.
Product Specifications
CAS Number
[221054-79-1]
Product Name Alternative
(+) -Equol
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-Equol.html
Concentration
10mM
Purity
98.68
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
OC1=CC=C2C[C@H](C3=CC=C(O)C=C3)COC2=C1
Molecular Formula
C15H14O3
Molecular Weight
242.27
Precautions
H302, H312, H332
References & Citations
[1]Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81 (5) :1072-9.|[2]Magee PJ, et al. Daidzein, R- (+) equol and S- (-) equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2. Eur J Nutr. 2014 Feb;53 (1) :345-50.|[3]Brown NM, et al. The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer. Carcinogenesis. 2010 May;31 (5) :886-93.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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