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(R) -Equol

(R) -Equol is an agonist of both ERα and ERβ with Kis of 27.4 and 15.4 nM, respectively.

Product Specifications

CAS Number

221054-79-1

Product Name Alternative

(+) -Equol

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/_R_-Equol.html

Concentration

10mM

Purity

98.68

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

OC1=CC=C2C[C@H](C3=CC=C(O)C=C3)COC2=C1

Molecular Formula

C15H14O3

Molecular Weight

242.27

Precautions

H302, H312, H332

References & Citations

[1]Setchell KD, et al. S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. Am J Clin Nutr. 2005 May;81 (5) :1072-9.|[2]Magee PJ, et al. Daidzein, R- (+) equol and S- (-) equol inhibit the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2. Eur J Nutr. 2014 Feb;53 (1) :345-50.|[3]Brown NM, et al. The chemopreventive action of equol enantiomers in a chemically induced animal model of breast cancer. Carcinogenesis. 2010 May;31 (5) :886-93.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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