25-Hydroxytachysterol3

25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398) . 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1[1].

Product Specifications

CAS Number

[39932-44-0]

UNSPSC

12352211

Target

Aryl Hydrocarbon Receptor; LXR; PPAR; VD/VDR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/25-hydroxytachysterol3.html

Purity

98.89

Smiles

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)(O)C)([H])C(/C=C/C3=C(CC[C@@H](C3)O)C)=CCC1

Molecular Formula

C27H44O2

Molecular Weight

400.64

References & Citations

[1]Slominski AT, et al., Metabolic activation of tachysterol3 to biologically active hydroxyderivatives that act on VDR, AhR, LXRs, and PPARγ receptors. FASEB J. 2022 Aug;36 (8) :e22451.