2'-O-Methylguanosine

2'-O-Methylguanosine is a modified nucleoside produced in tRNAs by the action of tRNA guanosine-2’-O-methyltransferase. 2'-O-Methylguanosine results in apoptotic changes of cells[1][2].

Product Specifications

CAS Number

[2140-71-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog

Type

Oligonucleotides

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/2-o-methylguanosine.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1[C@@H](OC)[C@H](N2C(N=C(N)NC3=O)=C3N=C2)O[C@@H]1CO

Molecular Formula

C11H15N5O5

Molecular Weight

297.27

Precautions

H302, H315, H319, H335

References & Citations

[1]B C Persson, et al. The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res. 1997 Oct 15;25 (20) :4093-7.|[2]T Mori, et al. Isolation and identification of apoptosis inducing nucleosides from CD57 (+) HLA-DRbright natural suppressor cell line. Biochem Biophys Res Commun. 1998 Oct 20;251 (2) :416-22.|[3]Petushkov I, et al., Effects of natural RNA modifications on the activity of SARS-CoV-2 RNA-dependent RNA polymerase. FEBS J. 2023 Jan;290 (1) :80-92.