Beauvericin-13C45

Beauvericin-13C45 is 13C labeled Beauvericin (HY-N6739) . Beauvericin is a cyclohexapeptide Fusarium toxin with insecticidal, antibacterial, anticancer, antiviral and cytotoxic activities. Beauvericin causes cellular genotoxicity by producing DNA breaks, chromosomal aberrations and micronuclei, and inhibits the PI3K/AKT pathway to induce apoptosis, thereby inhibiting the growth of HCC. In addition, Beauvericin affects immune function by inhibiting lymphocyte proliferation and interfering with the differentiation process of human monocytes into macrophages[1][2][3][4][5][6][7][8][9].

Product Specifications

UNSPSC

12352005

Target

Acyltransferase; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/beauvericin-13c45.html

Concentration

30.17 μM * 1.2 mL in Acetonitrile

Purity

Solubility

10 mM in DMSO

Smiles

[13CH3]N([13C@H]([13C](O[13C@]([13C](N([13C@H]([13C](O[13C@@H]1[13CH]([13CH3])[13CH3])=O)[13CH2][13C]2=[13CH][13CH]=[13CH][13CH]=[13CH]2)[13CH3])=O)([H])[13CH]([13CH3])[13CH3])=O)[13CH2][13C]3=[13CH][13CH]=[13CH][13CH]=[13CH]3)[13C]([13C@H](O[13C]([13C@@H](N([13C]1=O)[13CH3])[13CH2][13C]4=[13CH][13CH]=[13CH][13CH]=[13CH]4)=O)[13CH]([13CH3])[13CH3])=O

Molecular Formula

13C45H57N3O9

Molecular Weight

828.62

References & Citations

[1]Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo) . 1992 Oct;45 (10) :1626-32.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.